Janet Houghton is a distinguished fellow and endowed chair in Cancer Biology in the the Oncology Department. She leads research in determining the critical role of the transcription factor GLI in survival of colon cancer cells and other cancers that constitutively express GLI and mutant KRas genes. Her education and training were conducted in the United Kingdom with the Ph.D. degree conferred from the University of London. She moved to the United States, where she developed an independent career at St. Jude Children’s Research Hospital in Memphis, Tennessee, later moving to the Cleveland Clinic to focus on adult colorectal cancer, and subsequently joining Southern Research. Her research has resulted in the publication of 145 original peer-reviewed publications and 10 book chapters. She serves on several NIH Study Sections and has been Senior Editor for the international journal Cancer Research for over 12 years.