Our team of seasoned virologists, immunologists, and molecular biologists possesses extensive experience in understanding the pathogenesis, transmission, and control of emerging pathogens, encompassing a wide range of viruses, bacteria, and other infectious agents. We are proficient in a variety of in vitro and in vivo emerging pathogen assays, capable of evaluating the efficacy, safety, and pharmacokinetic properties of potential therapeutics and vaccines.
We offer a comprehensive suite of preclinical emerging pathogen services tailored to address the unique challenges posed by these evolving threats, encompassing every stage of the research process:
Target Identification and Validation: We help you identify and characterize novel emerging pathogens, providing crucial insights into their biology, epidemiology, and potential therapeutic targets.
Assay Development and Screening: We develop and validate assays to identify compounds that interact with potential drug targets and screen large libraries of compounds to identify promising drug candidates.
Hit-to-Lead Optimization: We optimize lead candidates by improving their potency, selectivity, and pharmacokinetic properties through structural modifications and synthetic chemistry.
Lead Candidate Selection: We assist in selecting the lead candidate most likely to succeed in clinical trials based on safety, efficacy, and pharmacokinetic evaluations.
Model Development, Validation, and Characterization: We develop and optimize animal models tailored to specific research objectives, ensuring their relevance and reproducibility. We thoroughly characterize animal models to understand their genetic, physiological, and immunological characteristics, providing researchers with a comprehensive understanding of the model system.
Preclinical Pharmacology and Toxicology Studies: We conduct a range of preclinical studies to assess the safety and efficacy of drug candidates, including animal studies, in vitro studies, and human studies.
Pharmacokinetics and Pharmacodynamics (PK/PD) Studies: We measure how a drug is absorbed, distributed, metabolized, and excreted by the body and determine its effects on the target and other organs and tissues.
Regulatory Support and IND/IND Preparation: We guide you through the intricate regulatory landscape, ensuring compliance with FDA guidelines and facilitating the preparation of Investigational New Drug (IND) and Investigational New Vaccine (IND) applications.