Neurodegenerative Disease Expertise

At Southern Research, we're devoted to transforming the treatment of neurodegenerative diseases via comprehensive research and innovative techniques. Our experts lead the way in combating diseases like Parkinson's, Alzheimer's, and other degenerative neurological conditions.


Navigating the Complexities of Neurodegenerative Diseases

our Partner in Preclinical Neurodegenerative Disease Research and Testing

In the intricate realm of neuroscience, neurodegenerative diseases stand as formidable adversaries, relentlessly eroding cognitive function and mobility. At Southern Research, we are committed to providing comprehensive preclinical neurodegenerative disease services, empowering researchers to unravel the complexities of these diseases and pave the way for groundbreaking therapies.

Our Expertise: Your Guiding Light in Neurodegenerative Disease Research

Our team of seasoned neuroscientists, neurologists, and molecular biologists possesses extensive experience in understanding the pathogenesis, progression, and potential therapeutic targets of a wide range of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. We are well-versed in a variety of in vitro and in vivo neurodegenerative disease assays, capable of evaluating the efficacy, safety, and pharmacokinetic properties of potential therapeutic compounds and cellular therapies.

Comprehensive Services Spanning the Neurodegenerative Disease Spectrum

We offer a comprehensive suite of preclinical neurodegenerative disease services tailored to address the diverse challenges posed by these diseases:

Neuroprotective and Disease-Modifying Compound Screening and Optimization: We utilize a range of in vitro and in vivo screening assays to identify promising neuroprotective and disease-modifying compounds, optimizing their potency, selectivity, and safety profile.

Pharmacokinetic and Pharmacodynamic (PK/PD) Studies: We determine the absorption, distribution, metabolism, and excretion (ADME) properties of potential therapeutic compounds, providing valuable insights into their pharmacokinetic profiles and pharmacodynamic effects in the central nervous system (CNS).

Regulatory Support and IND Preparation: We guide you through the intricate regulatory landscape, ensuring compliance with FDA guidelines and facilitating the preparation of Investigational New Drug (IND) applications.


Alzheimer’s disease is a progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out even the simplest tasks. It is the most common cause of dementia among older adults. The exact cause of Alzheimer’s disease is unknown, but it is thought to be caused by a combination of genetic, environmental, and lifestyle factors. One of the hallmarks of Alzheimer’s disease is the buildup of abnormal proteins called plaques and tangles in the brain. These proteins disrupt communication between brain cells and lead to cell death.

Learn more about our expertise in preclinical research and testing for Alzheimer’s disease treatments here.


Parkinson’s disease is a chronic and progressive neurodegenerative disorder that affects the nervous system and the parts of the body controlled by the nerves. It is characterized by a loss of dopamine-producing neurons in a specific area of the brain called the substantia nigra. Dopamine is a neurotransmitter that helps control movement. The exact cause of Parkinson’s disease is unknown, but it is thought to be caused by a combination of genetic, environmental, and lifestyle factors.

Learn more about our expertise in preclinical research and testing for Parkinson’s disease treatments here.


The Power of Collaboration

By partnering with Southern Research, you gain access to a wealth of expertise, resources, and infrastructure, enabling you to focus on your core competencies while we handle the complexities of preclinical neurodegenerative disease research and testing.

Our Experts

Corinne E.
Augelli-Szafran, Ph.D.

Vice President of Scientific Platforms

Donghui Bao, Ph.D.

Scientist III

Jay Russell, Ph.D.

Associate Director of Scientific Development

Unraveling the Mysteries of Neurodegenerative Diseases Together

At Southern Research, we are passionate about unlocking the mysteries of neurodegenerative diseases and contributing to the development of life-saving therapies. We are your trusted partner in addressing these challenging disorders, providing you with the expertise and support you need to make a lasting impact on the lives of millions affected by neurodegenerative diseases.

Contact us today to discuss your preclinical neurodegenerative disease research and testing needs, and let us help you pave the way for a future free from these devastating disorders.

Southern Research News

Southern Research awards biotech funds, bringing new jobs and business to Alabama

June 28, 2024

June 27, 2024, Birmingham, Ala – Southern Research has awarded more than $2.7 million in funds to eight biotech companies through a fund established as a result of the Innovate Alabama Tax Credit.
Read More

Southern Research Selects Chief Operating Officer

May 9, 2024

May 8, 2024 Birmingham, Ala. – Harry C. Ledebur, Jr., Ph.D., is joining Southern Research as Chief Operating Officer, bringing to the role more than 25 years of experience across the pharmaceutical, biotechnology, and contract-research industry. In his new position at Southern ...
Read More

Southern Research Awarded Grant to Develop Novel Antidotes for Arsenical Poisoning

April 11, 2024

Project Aims to Deliver Safer and More Effective Treatments for Cutaneous Injuries Southern Research is pleased to announce the award of a UG3/UH3 grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health (N...
Read More