Neurodegenerative Disease Expertise

At Southern Research, we're devoted to transforming the treatment of neurodegenerative diseases via comprehensive research and innovative techniques. Our experts lead the way in combating diseases like Parkinson's, Alzheimer's, and other degenerative neurological conditions.

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Navigating the Complexities of Neurodegenerative Diseases

our Partner in Preclinical Neurodegenerative Disease Research and Testing

In the intricate realm of neuroscience, neurodegenerative diseases stand as formidable adversaries, relentlessly eroding cognitive function and mobility. At Southern Research, we are committed to providing comprehensive preclinical neurodegenerative disease services, empowering researchers to unravel the complexities of these diseases and pave the way for groundbreaking therapies.

Our Expertise: Your Guiding Light in Neurodegenerative Disease Research

Our team of seasoned neuroscientists, neurologists, and molecular biologists possesses extensive experience in understanding the pathogenesis, progression, and potential therapeutic targets of a wide range of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. We are well-versed in a variety of in vitro and in vivo neurodegenerative disease assays, capable of evaluating the efficacy, safety, and pharmacokinetic properties of potential therapeutic compounds and cellular therapies.

Comprehensive Services Spanning the Neurodegenerative Disease Spectrum

We offer a comprehensive suite of preclinical neurodegenerative disease services tailored to address the diverse challenges posed by these diseases:

Neuroprotective and Disease-Modifying Compound Screening and Optimization: We utilize a range of in vitro and in vivo screening assays to identify promising neuroprotective and disease-modifying compounds, optimizing their potency, selectivity, and safety profile.

Pharmacokinetic and Pharmacodynamic (PK/PD) Studies: We determine the absorption, distribution, metabolism, and excretion (ADME) properties of potential therapeutic compounds, providing valuable insights into their pharmacokinetic profiles and pharmacodynamic effects in the central nervous system (CNS).

Regulatory Support and IND Preparation: We guide you through the intricate regulatory landscape, ensuring compliance with FDA guidelines and facilitating the preparation of Investigational New Drug (IND) applications.

Alzheimer's

Alzheimer’s disease is a progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out even the simplest tasks. It is the most common cause of dementia among older adults. The exact cause of Alzheimer’s disease is unknown, but it is thought to be caused by a combination of genetic, environmental, and lifestyle factors. One of the hallmarks of Alzheimer’s disease is the buildup of abnormal proteins called plaques and tangles in the brain. These proteins disrupt communication between brain cells and lead to cell death.

Learn more about our expertise in preclinical research and testing for Alzheimer’s disease treatments here.

Parkinson's

Parkinson’s disease is a chronic and progressive neurodegenerative disorder that affects the nervous system and the parts of the body controlled by the nerves. It is characterized by a loss of dopamine-producing neurons in a specific area of the brain called the substantia nigra. Dopamine is a neurotransmitter that helps control movement. The exact cause of Parkinson’s disease is unknown, but it is thought to be caused by a combination of genetic, environmental, and lifestyle factors.

Learn more about our expertise in preclinical research and testing for Parkinson’s disease treatments here.

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The Power of Collaboration

By partnering with Southern Research, you gain access to a wealth of expertise, resources, and infrastructure, enabling you to focus on your core competencies while we handle the complexities of preclinical neurodegenerative disease research and testing.

Our Experts

Corinne E.
Augelli-Szafran, Ph.D.

Vice President of Scientific Platforms

Donghui Bao, Ph.D.

Scientist III

Jay Russell, Ph.D.

Associate Director of Scientific Development

Unraveling the Mysteries of Neurodegenerative Diseases Together

At Southern Research, we are passionate about unlocking the mysteries of neurodegenerative diseases and contributing to the development of life-saving therapies. We are your trusted partner in addressing these challenging disorders, providing you with the expertise and support you need to make a lasting impact on the lives of millions affected by neurodegenerative diseases.

Contact us today to discuss your preclinical neurodegenerative disease research and testing needs, and let us help you pave the way for a future free from these devastating disorders.

Southern Research News

Southern Research opens new Station 41 biotech incubator for startups

January 23, 2024

Today, Southern Research marked the official opening of its Station 41 biotech incubator, which is one of four programs that make up the newly launched Station 41 biotech commercialization hub. The incubator provides wet lab space and office space, shared lab equipment and services to support ...
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Birmingham receives federal Tech Hub designation and opportunity to apply for millions in federal funding

October 23, 2023

Birmingham’s metro area is among 31 regions across the country named today as a federal Tech Hub, competing successfully under a new program that could ultimately inject $75 million into the local economy. The designation followed a highly competitive process with nearly 200 application...
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Coming soon to a doctor’s office near you: Access to cutting-edge research and care

March 17, 2023

By Josh Carpenter, Ph.D. Growing up in North Alabama, I remember watching movie trailers with excitement. They always ended with a deep voice that said, “opening soon in select theaters near you.” As it turns out, those openings were never “near me” since my local theater was not one ...
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