ProTide Drug Development & Testing

Accelerate Your Drug Discovery With Southern Research


ProTide Programs at Southern Research

Southern Research is a leading contract research organization (CRO) that specializes in the development and testing of ProTide drugs. We have a team of experienced scientists and researchers who are experts in all aspects of ProTide drug development, including:

    • Design and provide synthetic routes for the preparation of ProTides
    • In vitro and in vivo testing of ProTides
    • 31P-NMR technique to assess ProTides enzymatic stability
    • Development of manufacturing processes for ProTide prodrugs

We offer a comprehensive range of ProTide drug development services, including:

    • Feasibility studies: We can help you assess the feasibility of developing a ProTide drug for your target disease.
    • Lead optimization: We can help you optimize your ProTide lead compound to improve its safety and efficacy.
    • Preclinical testing: We can conduct all of the necessary preclinical testing to evaluate the safety and efficacy of your ProTide drug candidate in animal models.
    • Manufacturing development: We can help you develop a manufacturing process for your ProTide drug candidate, so that it can be produced at scale for clinical trials.

If you are developing a ProTide drug candidate, we encourage you to contact us to learn more about how we can help you accelerate your drug development.

Revolutionizing the Treatment of Viral Infections and Cancer

ProTide drugs are class of nucleotide prodrugs that have the potential to revolutionize the treatment of viral infections and cancer. ProTides are designed to deliver nucleotide analogs directly into cells, where they can be converted into active antiviral or anticancer drugs. Nucleotide analogs are synthetic molecules that are similar to the natural nucleotides that make up DNA and RNA.

Nucleotide analogs can be used to inhibit the replication of viruses and cancer cells. However, nucleotide analogs are typically not very effective orally because they are poorly absorbed from the gut and are quickly broken down by enzymes in the body. ProTides are designed to overcome these limitations.

ProTides are masked nucleotide analogs that are resistant to breakdown by enzymes in the body. Once inside a cell, ProTides are converted into active nucleotide analogs by enzymes that are present in all cells.

ProTide drugs have a number of advantages over traditional nucleotide analogs, including improved oral bioavailability, increased cellular uptake, and reduced side effects.

ProTide drugs are currently being developed for a variety of diseases, including:

  • Viral infections: HIV, hepatitis B, hepatitis C, Ebola, Zika
  • Cancer: leukemia, lymphoma, solid tumors


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