Subunit/Recombinant Protein-Based Vaccine Development

Recombinant protein-based vaccines are a type of vaccine that use a specific protein from a disease-causing virus or bacteria to trigger an immune response. The protein is produced in a laboratory using recombinant DNA technology followed by protein purification steps and evaluation of the produced protein. Recombinant protein-based vaccines are often combined with adjuvants. The recombinant protein-based vaccines are safe, effective, and fast-acting, and they can be developed fairly rapidly to respond to new threats. Examples of recombinant protein-based vaccines include SARS-CoV-2 (Novovax), Influenza, Hepatitis B, pneumococcal and meningococcal polysaccharide vaccines, and the Human Papillomavirus vaccine.

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Accelerate Your Vaccine Development with Southern Research

Southern Research is a leading contract research organization (CRO) that specializes in the preclinical development of recombinant protein-based vaccines. We have a team of experienced scientists and researchers who are experts in all aspects of recombinant protein-based vaccine development, including:

  • Design, construction, expression, and purification of recombinant protein-based vaccine candidates
  • Adjuvant selection, formulation, and stability testing for recombinant protein-based vaccine candidates
  • In vitro and in vivo testing of recombinant protein-based vaccine candidates
  • Assessment of the safety and efficacy of recombinant protein-based vaccine candidates in animal models
  • Assistance and consulting on the development and scale-up of a manufacturing process for recombinant protein-based vaccine candidates

We offer a wide range of preclinical recombinant protein-based vaccine development services, including:

    • Feasibility studies: We can help you assess the feasibility of developing a recombinant protein-based vaccine for your target disease.
    • Lead optimization: We can help you optimize your recombinant protein-based vaccine candidate to improve its safety and efficacy.
    • Preclinical testing: We can conduct all of the necessary preclinical testing to evaluate thesafety and efficacy of your recombinant protein-based vaccine candidate in animal models.
    • Manufacturing development: We can help you develop a manufacturing process for yourrecombinant protein-based vaccine candidate so that it can be produced at scale for clinical trials.

If you are developing a recombinant protein-based vaccine candidate, we encourage you to contact us to learn more about how we can help you accelerate your vaccine development.