AG129 mice were selected because they are highly susceptible to infection when challenged with the Puerto Rican strain of ZIKV, PRVABC59. As such, they serve as an ideal candidate for observing how the virus infection progresses in a living model. More specifically, the model is 100% lethal at subcutaneous challenge dose 1×101-1×105 PFU, and AG129 exhibit pronounced clinical signs of infection, such as weight loss and neurological indications that were not otherwise exhibited in other species.
In this sense, the NHP reacted to Zika in a manner much more similar to humans.
While cynomolgus macaque models are essential for studying the safety and efficacy of candidate ZIKV vaccines, clinical disease model such as AG129 provide a very useful tool for efficacy evaluation of ZIKV antivirals in “trigger to treat” testing.
Key findings, to date:
AG129 model is 100% lethal after subcutaneous challenge dose 1×101-1×105 PFU of the PRBABC59 strain.
Neurological signs are detected in a majority of the animals tested.
Presence of high serum viral load and high neutralizing antibodies (PRNT50) were evident in all AG129 mice tested.
The model is suitable for prophylactic and therapeutic antiviral drug efficacy evaluation.
In addition to NHP model, AG129 offers an alternative model for testing candidate Zika vaccines.
Preliminary Data (updated 8/3/2016):
In an effort to identify a vaccine for the Zika virus (ZIKV), Southern Research is running multiple animal model studies independently and through a contract with the NIAID in non-human primates (NHP).
The Southern Research board of directors has expanded to 15 members, with new additions representing a diverse range of national expertise.
The new members were recently approved by the University of Alabama System Board of Trustees and will join the current board in May 2022.
“Southern Research ...
Southern Research today announced key additions to its staff and leadership team.
Brantley Fry has joined the organization as its new vice president of People and Community. Fry served as state director for former U.S. Sen. Doug Jones and most recently has worked as chief of staff and general cou...
Three weeks after I joined Southern Research as president and CEO, a 12-story condo building collapsed in Miami, killing 98 people and raising alarms about the structural integrity of buildings across the country. This tragedy led many organizations to take a hard look at the safety of their phys...