The U.S. Food and Drug Administration approved pralatrexate — also known by its brand name, Folotyn — as the first treatment for a form of cancer known as Peripheral T-cell Lymphoma (PTCL), an often aggressive type of non-Hodgkins lymphoma. Southern Research collaborated with the Sloan Kettering Memorial Cancer Center and SRI International on development of the drug.
“We prepared and tested many compounds before finally identifying a substance that gave favorable results,” Southern Research’s Dr. Robert Piper said about the FDA’s approval of pralatrexate.”We are very glad our compound will help alleviate human suffering and extend lives.”
Folotyn was approved under the FDA’s accelerated approval process, which allows earlier approval of drugs that meet unmet medical needs. It is approved for patients who have relapsed, or have not responded well to other forms of chemotherapy.
Lymphoma is a cancer of the lymphatic system, which is part of the immune system.
Pralatrexate belongs to the class of chemotherapy drugs called antimetabolites, which prevent cell division and cause cancer cells to die. Antimetabolities are substances that interfere with DNA or RNA synthesis, disrupting cell division the growth of tumors.