Comprehensive Safety & Toxicology Services

Our toxicologists have decades of experience in the safety testing of small molecules, biologics, and novel therapeutics for the treatment of cancer. Vaccine safety and mRNA therapeutics have also been a major focus at Southern Research since the COVID-19 pandemic. Our team also have extensive experience with vectored vaccines and oncolytic viruses to treat cancer.

Our clinical pathology, immunology and in-vitro capabilities allow us to measure effects on the immune system by flow cytometry as well as anti-drug antibodies by ELISA, mRNA levels by PCR, and blood cytokine levels by Luminex and Mesoscale Discovery.

Our internal partnership with our Infectious Disease Department allows us to conduct efficacy and toxicity studies under biosafety level 3 containment. We have worked with government agencies to test novel vaccine delivery technologies, such as microneedle array patches and the reproductive safety of drugs and plant-derived dietary supplements. We offer standard PK, dose range-finding, and repeat dose GLP studies in small and large animal models, as well as biodistribution and neurovirulence testing of vaccines. Standard routes of administration include dermal, oral, intravenous, intradermal, intramuscular, intracranial, intranasal, intrathecal, and subcutaneous.