The Southern Research Toxicology Department works closely with our Infectious Diseases experts. We offer vaccine safety studies in rodents, rabbits, hamsters, and NHPs via the intranasal, intradermal, and intramuscular routes and have qualified novel microneedle array patches.
Over the past several years we have tested the safety of mRNA and adenoviral vectors for SARS-COV2, and oncolytic viruses. We offer neurovirulence testing of live-attenuated viruses in our Biosafety Level 2 and 3 facilities. We also offer stereotaxic surgery for local delivery of vaccines to the thalamus for NHPs or intracranially in mice.
Our in vitro scientists can evaluate immunogenicity testing before and after vaccination, as well as mRNA levels in serum and tissue biodistribution using ELISA and PCR methods. Our pathology and infectious disease groups can evaluate effects on the immune system via flow cytometry, blood chemistry, and histopathology in multiple animal species.
We can also measure inflammatory markers via Luminex and anti-drug antibodies via ELISA. We help our clients evaluate the safety and immunogenicity of novel adjuvant and vaccine combinations in animals as proof of concept related to potential clinical efficacy. We can also screen your vaccines for potential effects on embryofetal development to support use or testing in individuals of childbearing potential.
