Category: News

Southern Research technology to provide unique look at solar eclipse

A high-definition imaging system developed by Southern Research and deployed on NASA aircraft flying nearly 10 miles above Earth will give scientists a unique look at the Sun’s corona during a rare total eclipse taking place over the United States in August.

As a bonus, Southern Research’s Airborne Imaging and Recording System, or AIRS, will provide highly detailed observations of Mercury’s surface and could uncover the first solid evidence of the existence of vulcanoids, a belt of asteroids believed to be circling the Sun.

To capture this data, Southern Research and its AIRS/DyNAMITE technology are supporting the Southwest Research Institute (SwRI), which won a NASA contract to carry out the mission during the Aug. 21 eclipse.

Southern Research solar eclipse
Johanna Lewis, director of Engineering’s Program Management Office at Southern Research, poses with the AIRS/DyNAMITE instrument that will provide a unique look at the Sun and Mercury during the 2017 solar eclipse.

AIRS/DyNAMITE turrets will be mounted on two NASA WB-57 research aircraft, which will fly at 50,000 feet and collect high-resolution video and infrared data throughout the first total solar eclipse occurring over the length of the entire continental U.S. in 99 years.

“NASA is providing the WB-57 aircraft, Southern Research is providing the unique on-board sensors, and Southwest Research Institute is conducting the science,” said Johanna Lewis, director of the Program Management Office in SR’s Engineering Division.

“Southern Research will be handling the data collection, and we will be making sure that Southwest Research Institute is getting the best data that we can provide on Mercury and the Sun,” she added.

UNPRECEDENTED OBSERVATIONS

The total eclipse will unfold over 14 states, from Oregon to South Carolina, as the moon’s shadow completely blocks the Sun, turning day into night for a few minutes. For scientists, the event is a chance to get a close look at the otherwise hidden solar corona, as well as planets and stars normally obscured by the Sun’s blinding light.

SwRI says the mission will provide the clearest images ever of the Sun’s outer atmosphere and the first thermal images of surface temperature variations on Mercury.

“This airborne platform provides us with higher-quality, higher-speed images than are achievable from current or previous space-borne instruments,” said Amir Caspi, Ph.D., principal investigator of the project and a senior research scientist in SwRI’s Boulder, Colorado, office.

“We hope to better understand what causes the corona and why it’s so hot. It’s millions of degrees Celsius, hundreds of times hotter than the visible surface below,” he added. “The corona is the source of electromagnetic storms here at Earth, which can damage satellites, cause power grid blackouts, and disrupt communication and GPS signals, so it’s important to better understand it.”

‘EYES IN THE SKY’

Southern Research AIRS
Three NASA AIRS/DyNAMITE-equipped WB-57 aircraft fly over Houston.

Lewis and John Wiseman, Ph.D., a senior project leader in Southern Research’s Engineering Division, traveled to NASA’s Johnson Space Center in Houston this month for test flights of one of the WB-57 aircraft with an AIRS/DyNAMITE instrument modified for the mission.

“The system provides a means of tracking events you might not be able to get elsewhere, with simultaneous mid-wave infrared and visible light data,” said Wiseman, one of the instrument’s inventors. “It’s configurable, and we have had a number of payloads in it, so it’s very versatile.”

Southern Research developed the technology in partnership with NASA, which was looking for a system to capture HD video of the July 26, 2005, launch of the Space Shuttle’s “Return to Flight” mission after the Columbia mishap. Acting as “eyes in the sky” for NASA, the system, from a distance of 20 miles, captured full-motion video of the shuttle’s lift-off and tracked it to 146,000 feet.

“It was developed as an experiment, and it was supposed to have about five to 10 flights,” Wiseman said.

Since then, the high-altitude video system has been used to monitor critical rocket launches, to collect data for science missions, and to assist the Department of Defense on security missions. In the past six years alone, the AIRS/DyNAMITE technology has flown on nearly 500 flights.

EXTENDED VIEW OF ECLIPSE

On Aug. 21, the twin WB-57 aircraft flying in the stratosphere over Carbondale, Illinois, will tag-team the total eclipse, gathering exceptionally accurate measurements of the solar corona to better understand how energy moves throughout the Sun’s atmosphere, according to NASA.

From a vantage point high above the clouds and Earth’s weather systems, the AIRS/DyNAMITE-equipped planes will get a clear view of the eclipse and collect data during totality for around eight minutes. That’s far longer than the 2 minutes and 40 seconds available to ground stations monitoring the event.

In addition, the instruments will be in position to make unprecedented observations of Mercury’s surface in infrared light, which can be otherwise hindered by radiation from the Sun. Scientists hope these measurements will give new information about how Mercury’s surface temperature changes as its day turns to night, shedding light on its surface composition, NASA says.

“Because Mercury is so close to the Sun, it’s very difficult to perform direct observations. When the moon is going into eclipse over the Sun, we will have a rare opportunity to collect Mercury infrared data,” Lewis said.

There’s even more to this mission. While the Sun’s bright light is blocked, AIRS’ HD cameras will search the skies for evidence of vulcanoids, a hypothetical band of asteroids traveling around the Sun in Mercury’s atmosphere. That’s important because vulcanoids could provide insights about the creation of the planets and the solar system’s earliest period.

“Most people have never heard of vulcanoids before. This will be an unique opportunity for them to look for these things that scientists theorize are there, but nobody has ever proven,” Lewis said. “If we provided the instrument that proves they were there, that would be a major accomplishment.”

FLYING WITH THE WB-57

Southern Research will play another important role in the eclipse mission. A Houston-based SR communications engineer, Donald Darrow, will serve as the special equipment operator in the back seat of one of the WB-57 aircraft, operating the AIRS/DyNAMITE instrument during the flight.

Lewis said a Southern Research team on the ground at NASA’s Johnson Space Center will assist Darrow on the mission.

“We can be another set of eyes, seeing what he’s seeing. If we see there are any adjustments he needs to make – open the camera’s iris more, sharpen the focus – we can call that up to him,” she said. “We’ll be doing the same for the other back-seater when it’s his turn.”

To make sure the scientists at SwRI’s Colorado labs get the data they need, the AIRS/DyNAMITE equipment flying on the mission have received modifications including software upgrades and a filter to protect the visible light camera. In addition, new video recorders that capture a full range of data have been added.

“This is one of the most exciting missions for this technology,” Wiseman said.

Southern Research taps Mark Patterson for aerospace business development role

Mark Patterson, an engineer and innovator with broad experience across a sweeping range of technology disciplines, has joined Southern Research’s Engineering Division to lead business development efforts focusing on the aerospace industry.

Over a 30-year career, Patterson, Ph.D., has made significant technical contributions to fields as diverse as advanced materials and climate change research. He has been heavily involved in all aspects of R&D projects and worked with key government agencies and major defense contractors.

For Southern Research, Patterson will concentrate on identifying new business opportunities and potential collaborations for the organization’s engineering team.

Mark Patterson Southern Research
Mark Patterson, left, discusses Southern Research’s AIRS technology with engineer John Wiseman, one of the developers, in the Systems Development Integration Lab.

The Engineering Division’s areas of specialization include high-temperature testing of materials, non-destructive evaluation technologies, mechanical testing of components in extreme conditions, and the development of complex sensing devices.

“Mark brings a richly diverse background that is highly relevant to our specialized technical areas at Southern Research,” said Michael Johns, vice president of Engineering at the Birmingham-based non-profit organization.

“With his wide-ranging expertise, Mark can help us build on fields where we are already industry leaders and pinpoint new opportunities in disciplines where we can grow to become leaders,” he added.

DIVERSE CAREER

Patterson has considerable experience in research and development activities, having managed $60 million in projects spanning the complete R&D lifecycle, from funding acquisition to technology development and product delivery.

He has directed efforts involving an array of different technologies – sensors, advanced materials, ceramics, additive manufacturing, autonomous systems, and mineral extraction, among others. He’s also been involved in efforts focusing on climate change, artificial bone implants, nuclear waste, energy, environment, and counter terrorism.

In addition, Patterson introduced new manufacturing techniques for advanced ceramic materials and devised methods to fabricate transparent armor, infrared windows and domes, and machine tool inserts. He also supported pioneering robotics operations that used autonomous platforms to collect climate change data from volcanoes and glacial lakes, as well as through atmospheric profiles.

He has given numerous presentations at national and international conferences, published more than 80 papers, and holds four patents. He served as the technical secretariat for a U.S. Department of Defense handbook on ceramic matrix composites, a revolutionary lightweight material capable of withstanding extreme temperatures, and worked as a consultant to the Defense Advanced Research Projects Agency (DARPA).

EQUIPPED FOR GROWTH

Southern Research engineering
Mark Patterson has been named director of business development-aerospace for Southern Research’s Engineering Division.

Patterson said Southern Research’s longstanding partnerships with NASA, defense agencies and aerospace companies, along with an extensive set of technical capabilities, mean the Engineering Division is well positioned for growth opportunities.

“In aerospace engineering, there are several areas where Southern Research can have a significant footprint in the future. Obviously, we’re well established in high-temperature testing of materials, and we will maintain world leadership in that,” Patterson said.

“I’d like to see Southern Research continue our development in advanced additive manufacturing technologies,” he added. “The development and use of additive manufacturing is going to require new qualification protocols and test methods, and we are well positioned to become world leaders in this area.”

Patterson has previously worked with the Birmingham-based organization’s Materials Research Department, which has made important contributions to the nation’s space program and to defense projects.

“Mark has ties to Southern Research. Over the years, he has collaborated on various projects with the Materials Research Department,” said Jim Tucker, the department’s director. “We have had the pleasure of working with Mark for over 20 years. His insight into complex technical problems is well known in the industry and will be of great value to Southern Research.”

Patterson has previously worked in research and technology roles for small businesses, Advanced Ceramics Research and Hydronalix, in Arizona; the University of Arizona, as director of research initiatives; and defense contractor BAE Systems, where he focused on unmanned aerial vehicles and advanced ceramics.

Patterson holds a doctorate in materials science from the University of Cambridge in England, a master’s degree in materials science from Queens University in Canada, and a bachelor’s in mining engineering/mineral processing from Camborne School of Mines at England’s Exeter University.

Southern Research engineer John Koenig receives notable industry award

Southern Research engineer John Koenig was awarded the distinguished Thermal Conductivity Award by the governing board of the International Thermal Conductivity Conference (ITCC).

Southern Research engineering
During a long career at Southern Research, John Koenig made important contributions to thermophysics and the nation’s space program.

This award, established in 1970, honors outstanding researchers, educators, and industrialists who have contributed significantly to the field of thermophysics. The traveling award is engraved with the roster of past recipients’ names including giants in this discipline.

The nomination process is conducted by a committee of the board, and then selection is made upon due deliberation of the entire board. The awardee is nominated based on a variety of achievements that could include a singular key development such as a key theory or measurement method, a significant long-term involvement in thermal science or engineering activities, or the growth of the ITCC.

Koenig’s selection for the award was based on this process, taking into consideration his longstanding technical achievements, his organization of the 29th ITCC in Birmingham in 2007, and his service during two terms as chairman of the ITCC governing board.

Additionally, he has directed meaningful measurements in the field of thermophysical properties of materials, and his work has involved numerous government contracts with a high level of difficulty.

“I am honored to be selected by my peers to join this corps of notable men and women who have contributed so greatly to the thermal conductivity discipline,” Koenig said. “The ITCC and this award bring deserved recognition to a field that is integral to the defense and aerospace industries.”

Koenig’s career spanned 39 years at Southern Research, where he concentrated on materials research and development and led teams of engineers as director of materials research. He is currently a consultant to the Birmingham-based research organization, investigating methods to develop and test new advanced materials with multiple space applications.

“John’s career contributions to the thermal conductivity field have placed Southern Research on the map as a national leader in hypersonics, thermal properties characterization and evaluation of high-temperature materials for leading contractors like NASA and the Department of Defense,” said Mike Johns, vice president of Engineering at Southern Research.

“He continues to play a critical role in this industry and in guiding our Engineering team toward success.”

Last year, NASA honored Koenig for significant contributions to the nation’s space program.

Southern Research probe of Zika looks into ‘rebound virus’

Southern Research scientists are investigating how the Zika virus is able to find a safe harbor in an infected host’s tissue and stage a rebound weeks after the virus was seemingly cleared by the immune system.

Evidence of a Zika virus rebound, called a “secondary peak” following an initial infection, emerged during a Southern Research-funded project to determine how the virus progresses in infected cynomolgus macaques.

In that study, researchers found an ever increasing presence of viral RNA, a scientific marker for the presence of the virus itself, in the testes of monkeys. Prolonged shedding of the virus was also detected in urine.

“We hypothesized that the Zika virus is using the immune privileged tissue as a reservoir and going dormant, or in low replication mode, just hiding there,” said Fusataka Koide, associate director of infectious disease research at Southern Research.

Koide and fellow SR staff, Laurie Queen and Priscilla Williams, view a viral titer plate to determine if a drug presents the growth of Zika virus.
Koide and fellow SR staff, Laurie Queen and Priscilla Williams, view a viral titer plate to determine if a drug prevents the growth of Zika virus.

“When the immune status changes in the host, the virus could surge again,” he added. “An adaptive mutation and selection process post-infection could also contribute to successful establishment of Zika virus in a host.”

While a deeper understanding of this Zika virus rebound is needed, a possible mutation-driven secondary peak of the virus could pose new challenges for companies attempting to develop anti-viral therapeutics for post-infection treatment.

“They’ll need to study the mechanism of how the infection occurs to come up with an effective strategy for the drug,” Koide said. “Maybe it will prevent the initial viremia, but it could come back later on. They’ll need to know the drug can penetrate those tissues that may be harboring Zika virus.”

MEETING AN URGENT NEED

Zika virus infection exploded as a global health threat in early 2016. Since then, Southern Research has been heavily involved in the scientific community’s efforts to better understand the virus’s pathogenicity and has assumed a leadership role in providing efficacy models for evaluation of potential vaccines and anti-viral treatments.

Last year, the National Institute for Allergies and Infectious Diseases (NIAID), a division of the National Institutes of Health (NIH), contracted Southern Research to develop a non-human primate model for evaluation of candidate novel therapeutics and vaccines for protection and control of Zika virus infection.

Koide said potential vaccines are now being tested in macaques, with promising results in a proof-of-concept study that demonstrated that an immune system response had been triggered against the virus. In August, he said, efficacy studies will begin with potential new anti-viral compounds.

In addition to non-clinical research, Southern Research is now providing Phase-I clinical trial support for pharmaceutical companies that are working to develop vaccines against the Zika virus, Koide said.

While fears about Zika virus infection have somewhat faded since last summer, Koide said that it remains a threat and there is still an urgent need for both an effective vaccine and anti-viral treatments.

Last year’s outbreak of the virus in Brazil and South and Central America led to a significant increase in the number of children born with microcephaly, or an unusually small head. Cases of Guillain-Barré Syndrome and other neurological disorders were also reported.

“Vaccines are a preventative measure, which is probably the most effective strategy to fight Zika virus infection,” Koide said. “But some populations — pregnant women, the elderly, and immune-compromised individuals — may not be able to receive a vaccine and will need to rely on anti-viral drugs for protection.

“That’s important. You need both arms – vaccines and anti-viral drugs to fight the virus,” he added.

What you need to know about Zika virus transmission.

 

Researchers viewing the device counting the number of areas on the plate where the Zika virus is replicating.
Researchers viewing the device counting the number of areas on the plate where the Zika virus is replicating.

REBOUND RISKS

Meanwhile, Southern Research scientists are also working to completely understand the Zika virus’s ability to stage a rebound. Just how does the virus manage to survive in a host after an initial onslaught by the immune system appears to eliminate it?

To study the escape process, they’ve isolated the virus from the first acute infection phase, and later, from the secondary peak, so they can examine genetic differences between the two viral populations in order to determine if specific changes in RNA sequence might be associated with the rebound.

This kind of rebound is not seen in similar viral diseases such as Dengue fever, making Zika virus unique, Koide said.

“We just don’t know what triggers the rebound,” he added. “That is something we need to tease out because it’s RNA we’re detecting, not an infectious particle per se. Studying Zika virus’s ability to persist in immune privileged tissues (such as testes) could have important implications for non-vector mediated transmission of Zika virus.”

And while the rebound virus is eventually cleared by the macaques, Koide said revealing the Zika virus’s safe harbors is critical to evaluating whether there’s a risk that the rebound could change how the infection progresses in humans, either through enhanced transmission or potentially escalating clinical complications.

“Understanding the role viral reservoirs play in Zika virus’s immune escape should provide strategic insights for the development of new vaccines and therapeutics,” Koide said.

First TrainSafe class focuses on biosafety measures for lab workers

Southern Research’s first TrainSafe class at its new, state-of-the-art biosafety training center in Birmingham attracted eight laboratory professionals for an intensive four-day session on effective protective measures against deadly pathogens.

“I think a class like this could help leadership and safety officers and scientists all learn the mindset that we’re all here together and we need to make rules we can live by,” said Heather Engelmann of the Pacific Northwest National Laboratory in Richland, Washington.

“Biosafety is the topic, but it’s really about behavioral sciences and how to lead well.”

Called the Advanced Biological Risk Mitigation Program, the class beginning June 6 taught research and clinical lab workers how to reduce risk to themselves and others in a simulated Biosafety Level 3 (BSL-3) laboratory.

For Keith Mulholland, a molecular biologist at the U.S Department of Homeland Security’s BioWatch Program, the most useful parts were hands-on exploration of the personal protective equipment (PPE) and instructor Sean Kaufman’s stories.

“I’m definitely going to go through and reread all my protocols, look at everything, and really try to see where these techniques would come in handy,” he said. “Also, when I’m working, I’ll try to implement them and see how I can better protect myself and my coworkers.”

As with any comprehensive class, each student gleaned something different. For Engelmann, the most useful aspect “was how to frame conversations about how to help employees change their behavior,” she said.

REDUCING RISKS

Kaufman, a national biosafety expert and behavioral psychologist, led the class. In addition to physical risk prevention techniques, he also taught ways to lessen the risk of a cyber attack and strategies to contain human risk. A second part to the program will teach healthcare first responders like doctors, nurses, and EMS workers protective measures to use when treating a patient with one of these potentially dangerous infectious diseases.

“Many emerging infectious diseases require a new set of skills,” Kaufman said. “These bugs often do not have vaccinations, can be transmitted through aerosol, and are things like MERS or SARS that make healthy people sick.

Sean Kaufman leading the first of many classes at Southern Research’s new TrainSafe center.
Sean Kaufman leading the first of many classes at Southern Research’s new TrainSafe center.

“They could very quickly overburden or overrun our capacity to respond appropriately, even in a very well-developed country,” he said.

IMPORTANT MISSION

It’s a risk that Kaufman is all too aware of. In 2014, he trained Emory University doctors and nurses in preparation for caring for Ebola-infected patients. No one there was infected, but two nurses in Dallas were sickened just weeks later. “It’s clearly apparent that a blending of infection control and biosafety lessons that we’ve learned in high-risk containment could benefit the healthcare industry as a whole.”

Before overseeing the high-risk isolation unit, Kaufman had 10 years of experience in biosafety training. The decision to build the simulation center was made after Kaufman had been working with Southern Research as a consultant.

“Southern Research has a rich history and tradition of leading scientific innovation and of developing culture within science,” he said. “This type of training center coincides with that overall mission.”

Art Tipton, Ph.D., president and CEO of Birmingham-based Southern Research, said the organization can play an important role in better preparing lab workers, emergency responders and hospital staff against emerging threats.

“We, of course, see this as a strategic opportunity to work with the premier trainer in the region, but also as being key to the Southern Research mission as a chance to enhance the biosafety of our nation and the people who work in this important space,” Tipton said.

In addition to the BSL-3 lab, the center also houses an ambulance bay, patient room, and staging areas for students to practice putting on and taking off personal protective equipment (PPE).

Unlike active labs or hospitals, these spaces do not have to be decontaminated or shut down for training. Further, attendees can learn to treat patients with unknown infections without the risk of being infected themselves.

“It’s an amazing facility,” said Pacific Northwest National Lab’s Engelmann. “It’s kind of fun to be the first class through.”

Prosperity Fund targets revitalization, job growth in Alabama coal counties

With backing from the Appalachian Regional Commission (ARC), Southern Research is launching The Prosperity Fund, a $2.4 million initiative to accelerate entrepreneurial activity and spark job creation in four Alabama counties rocked by the coal industry’s steep downturn.

The Prosperity Fund’s goal is to foster new start-up businesses and assist selected small firms in Fayette, Walker, Tuscaloosa and Jefferson counties, according to Corey Tyree, Ph.D., director of Energy & Environment-Alabama for Southern Research and project leader.

“Southern Research was founded to help Alabama remain resilient in the face of economic change by strengthening our existing industry and helping develop new ones,” Tyree said. “This is about making what we have stronger, reinventing our economy.”

The Prosperity Fund will assist small businesses in four Alabama counties hurt by the coal industry's downturn.
The Prosperity Fund will assist small businesses in four Alabama counties hurt by the coal industry’s downturn.

The four counties being served by The Prosperity Fund represent the core of Alabama’s traditional coal country, and they have been hit hard by the industry’s decline. Since 2012, the counties have seen 12,000 jobs tied to coal mining disappear, resulting in $800 million in lost wages.

“These four Alabama counties have accounted for 10 percent of the coal job losses in the nation,” Tyree said. “But this initiative focuses on moving forward. We have to look for new approaches to job growth and seek out new opportunities for these counties.”

CREATING A SUPPORT SYSTEM

The Prosperity Fund, established as public-private partnership, will link Southern Research with community officials, business leaders and potential investors in a network to provide broad-based support for entrepreneurship in the four counties.

Tyree said the team will recruit and mentor existing businesses and start-ups, assisting them with fundamental activities such as customer discovery, market research and fundraising. It will work with venture capitalists, angel investors and other sources to raise funds to support business growth.

“This award is part of a blueprint for new jobs, fresh opportunities, and a robust economic future for Alabama,” said ARC Federal Co-Chair Earl F. Gohl. “It is bringing added capital into the region and help Appalachia prepare to globally compete in manufacturing, technology, local agriculture, construction, and a variety of other industry sectors.”

The Prosperity Fund has set a goal of facilitating the creation of 10 new businesses. Other objectives are:

  • Creating 80 jobs through business improvement and creation efforts
  • Increasing business revenue by $11 million
  • Leveraging $6 million in private investment
  • Assisting 10 existing businesses

Paul Kennedy, president of the Walker Area Community Foundation, said the Prosperity Fund can act as a catalyst for revitalization in a county with deep roots in the coal industry. Since 2012, Walker has lost more than 500 coal jobs, making it one of the 25 most severely impacted counties in the nation.

“Southern Research has 75 years worth of economic development experience,” Kennedy said. “To be able to bring in a nationally recognized organization with their technical expertise, networks, and knowledge to work with our businesses just really excites me.”

Kennedy said he believes that entrepreneurial successes spurred by the Prosperity Fund can inspire others in Walker County.

“When people are getting laid off, everybody is kind of blue. First, it’s the miners. Then it’s the insurance company. Next, the restaurant,” he said. “The same thing happens in reverse when there is a positive development. The excitement ripples through the community, and optimism ripples.”

ECONOMIC DEVELOPMENT

image007The Prosperity Fund stems from an ARC-funded study by Southern Research that examined strategies to boost job creation in Alabama’s coal region. As part of that project, Tyree’s team engaged with educators, economic development professionals, investors and others to build a coalition of advocates for renewal efforts.

The ARC is supporting The Prosperity Fund with a $1.2 million grant. Southern Research and its partners are matching the rest of the 30-month project’s total cost.

“The Prosperity Fund project is another example of changing views of what economic development looks like,” Tyree said. “One, it aligns with the idea that small businesses are the heart of the jobs economy.

“And two, it’s also consistent with the idea that technology-based economic development strategies that suggest our community needs innovation assets like Southern Research to play a role in economic revitalization,” he added.

Tyree believes momentum generated by The Prosperity Fund in the four coal counties will encourage private support that will extend its existence beyond the 30 months of the ARC funding.

Kennedy hopes that’s the case.

“I hope this becomes a real marriage between their capacity and our capacity,” he said. “Southern Research is on the cutting edge of research in technology, energy, water, pharmaceuticals. Just to know that they are paying attention to the wants, needs, aspirations and talents of my community is exciting.”

Southern Research taps Lillie Ryans as director of contracts

Southern Research announced today that Lillie Ryans has joined the Birmingham-based organization as director of contracts, following an extensive nationwide search to fill this key position.

Ryans comes to Southern Research after nine years as contracts director at SRI International, a Menlo Park, California, non-profit research center that like Southern Research focuses on serving government and industry clients. A deeply experienced contracts professional, Ryans has worked in the field for more than 30 years.

Southern Research Lillie Ryans
Lillie Ryans is joining Southern Research as its new director of contracts.

“Complementing our strong science and engineering are great administrative functions. Critical among these are contracts, which define how we work with our government and commercial clients,” said Art Tipton, Ph.D., president and CEO of Southern Research.

“Lillie has the experience and talent to help us continue and improve our strong contract processes in a way that drives additional growth,” Tipton added. “We’re thrilled to have her on board.”

At Southern Research, Ryans takes charge of a contracts team with a dozen staff members working in close coordination with the organization’s Drug Discovery, Drug Development, Engineering, and Energy & Environment divisions.

The team negotiates and manages contracts with government organizations such as NASA, the National Institutes of Health, and the Department of Defense, as well as commercial enterprises including large pharmaceutical and aerospace companies.

“In this highly visible role, Lillie’s leadership style will strengthen the collaboration among the contracts team and across all of our divisions, now and into the future,” said Michael Catalano, a Southern Research vice president and general counsel.

Southern Research Lillie Ryans
As Southern Research’s director of contracts, Lillie Ryans will work closely with Michael Catalano, vice president and general counsel.

“In addition to the day to day management of responsibilities, Lillie will identify opportunities for process improvement, lead training and development initiatives for the contracts team, and help to integrate certain functions of the intellectual property department into the contracts team.”

“I appreciate the kind of work being done at Southern Research and the impact it has on the lives of people,” Ryans said. “Activities like cancer research and Alzheimer’s research resonate with everybody. I look forward to being part of an organization that has a powerful vision and mission.”

At SRI International, Ryans was responsible for providing pre-award management for research contracts generating revenue exceeding $500 million. Prior to that, she served as director of Engineering Research Administration at Stanford University and as deputy director of the Office of Sponsored Research, where she provided pre- and post-award management.

She holds a master’s degree in procurement and contract management from Golden Gate University in San Francisco and a bachelor’s degree in business administration from Stillman College in Tuscaloosa, Alabama.

Researching radiosensitizers, a new class of drugs that would make tumors more vulnerable to radiation therapy

Two out of three cancer patients are treated with radiation, but the therapy often fails to wipe out the tumor or slow its growth. Southern Research is working to develop a new class of drugs that will help the radiation deliver a more powerful punch to the disease.

Dr. Bo Xu, M.D., Ph.D., Distinguished Fellow and Chair of Southern Research’s Oncology Department, said a radiosensitizer, as this kind of drug is known, would greatly benefit cancer patients by improving the success rate of radiation by reducing resistance to the treatment.

“Our project focuses on making those tumor cells more vulnerable to radiation by targeting a critical survival mechanism that allows them to recover from the effects of radiation,” Xu said.

It’s a challenging project, in the works for almost a decade. It got started when Southern Research scientists began looking at fundamental biology concepts to identify a pathway that could play a role in the ability of cancer cells to survive radiation.

Southern Research Bo Xu radiosensitizer
Southern Research’s Dr. Bo Xu is working to develop a radiosensitizer, a drug that would make tumors more vulnerable to radiation therapy.

They discovered that disrupting the tumor’s self-protection mechanism – in this case, an interaction between two specific proteins – makes the cancer more sensitive to radiation treatment, Xu said.

“The whole idea is to use this strategy to find a new drug that can be used by patients who receive radiation. This drug wouldn’t have toxicity because if it got into the cell it wouldn’t mess up the major functions of the protein network,” he said.

“It would only work when radiation is delivered, and that radiation would be more effective. It’s like a catalyst.”

Using funding from the Alabama Drug Discovery Alliance (ADDA), a partnership with the University of Alabama at Birmingham, Southern Research scientists recently scanned thousands of compounds to identify potential drug candidates. The focus now is to validate the results of those scans and to identify lead compounds for more testing.

“Our hope is that in three years, we can identify a novel class of radiosensitizers that can help the approximately two-thirds of cancer patients who will eventually receive radiotherapy,” Xu said.

CRITICAL INTERFERENCE

While some forms of cancer, such as lymphoma, are sensitive to radiation therapy, many others are not. Solid tumors with a low supply of oxygen, called hypoxic tumors, are tough to treat with radiation. So are cancer cells with a high DNA-repair capability.

To develop a radiosensitizer, Xu is taking aim at a protein that binds to DNA and recognizes the damage being done by radiation. The protein then joins forces with an enzyme to initiate a molecular repair job.

“If that recruitment is successful, then the DNA damage will be repaired, and the cancer cell will survive,” Xu said. “What we’re trying to do is to block this protein from finding the other one, so that the repair process will be diminished or affected. That way, the tumor cells will die.”

To prevent the DNA repair job from getting started, Xu is investigating a small peptide mimic, a small sequence of amino acids that is similar to a human protein but just a fraction of its size. These strands get to the site to block the interaction of the two natural, full-size proteins.

“This interference makes the cancer cell more vulnerable to radiation treatment,” he said.

Radiosensitizers are in demand, but they have proved difficult to develop. While the concept has been around for half a century, very few radiosensitizers have actually become available, according to Xu.

“While there are compounds that work synergistically with radiation, there are few drugs that were developed as a pure radiosensitizer,” he said.

In addition to the ADDA, the National Institutes of Health and the Department of Defense prostate cancer program have provided Southern Research with funding for this research over the years.

Southern Research initiates intensive TrainSafe biosafety training program

Southern Research is launching a new biosafety training center as the centerpiece of an advanced program called TrainSafe to teach health care workers and laboratory staff how to protect themselves against pathogens responsible for serious infectious diseases.

Sean Kaufman, a national biosafety expert who prepared Emory University Hospital caregivers to treat two Ebola-infected patients in 2014, will direct training at the state-of-the-art Southern Research facility, which features a simulated Biosafety Level 3 (BSL-3) laboratory, ambulance bay, and hospital room.

Southern Research’s first TrainSafe class, focusing on biological risk mitigation in a BSL-3 lab, is scheduled to begin June 6. Click here to register.

Southern Research biosafety training
Sean Kaufman, a noted biosafety expert, will direct the classes at Southern Research’s new TrainSafe center.

“The Southern Research center is new and innovative, and I think this is a life-saving program that can help to protect entire communities,” said Kaufman, CEO and founder of Behavioral-Based Improvement Solutions in Atlanta.

“The consequences of having a laboratory staff member not being prepared to work with these very dangerous pathogens could be huge,” he added. “They could bring this home to their families. They can start outbreaks like we saw with SARS in China and Canada that go worldwide.”

A second tier of the TrainSafe program focuses on protective measures that front-line health care workers – doctors, nurses and emergency responders – need to use when encountering a patient suffering from a potentially deadly infectious disease.

“At Southern Research, we’re going to be training folks to make sure they do the right things when they are treating people with serious infectious diseases. We cannot repeat what happened in 2014 with the two nurses getting sick while treating an Ebola-infected patient in Texas,” Kaufman said.

HANDS-ON TRAINING

Art Tipton, Ph.D., president and CEO of Birmingham-based Southern Research, said it’s crucial that research laboratories and hospitals across the United States embrace a culture of safety and preparedness due to the rising threat of dangerous infectious diseases including Ebola, avian influenza and MERS.

“The multi-dimensional TrainSafe center demonstrates Southern Research’s commitment to being a leader in improving training and critical safety practices in environments such as laboratories and health care facilities. We are thrilled to be working with Sean on this important program,” Tipton said.

“Virulent infectious diseases are a growing public health threat, and this training program at our one-of-a-kind center will help lessen the risks posed by the unintentional spreading of these emerging diseases,” he added.

Southern Research biosafety training
Southern Research’s TrainSafe facility includes a realistic simulated BSL-3 lab for the program’s biosafety training.

The TrainSafe facility is designed to permit practical, hands-on training in authentic environments. An advantage of the highly realistic mock BSL-3 lab is that training can take place at any time, unlike a fully operational lab, which would have to be shut down and decontaminated.

The ambulance bay and isolation room section of the TrainSafe center is designed to mimic the arrival of a severely sick patient for hospital care. Patient transport can be extremely hazardous for caregivers, who are often not prepared for contact with unfamiliar and dangerous infections.

Changing rooms in the facility will be used to instruct trainees how to safely put on, and take off, personal protective gear, including masks, gowns, gloves, positive-pressure respirators and full hazmat suits. Knowing how to remove this gear properly is particularly important in preventing accidental infections.

“Training is an opportunity to shake things up, challenge perceptions and make sure people are operating in a safe and effective manner while working in these situations,” Kaufman said.

COUNTERING EBOLA

Southern Research biosafety training
Southern Research’s new TrainSafe center includes a mock ambulance bay for biosafety training for emergency responders.

Kaufman, a behavioral psychologist, has extensive biosafety training experience. He managed a training program at a simulated BSL-3 lab at another institution for 10 years and has conducted biosafety training for the Centers for Disease Control and Prevention, where he once worked.

In 2014, Kaufman conducted training exercises for doctors and nurses at Emory before two American volunteers working in West Africa during the Ebola outbreak arrived at the Atlanta hospital for treatment. He remained at the hospital to provide safety expertise during their care.

While no one was infected with Ebola there, the danger was highlighted later that year when two nurses at a Dallas hospital were infected with the virus while treating a patient who had contracted the disease while in Africa.

Kaufman says that episode underscores the need for more intensive training for health care workers.

“We have people working with very dangerous pathogens and very sick patients, and they don’t know what they are doing,” he said. “In working with laboratories over the last 12 years, I have had a chance to see that no matter where you are in your career, you still need training.”

During the decade he managed the training lab, Kaufman said more than 10,000 professionals from the global scientific community participated in the biosafety program. He expects a similar response to Southern Research’s TrainSafe initiative.

“This is an international program,” Kaufman said. “People will come from around the world.”

Engineers put NASA inflatable heat shield materials through testing

Southern Research engineers conducted tests that advanced an experimental NASA technology designed to solve a tough challenge in landing people and cargo on Mars – slowing down a spacecraft entering the Red Planet’s thin atmosphere to permit a safe touchdown.

The Hypersonic Inflatable Aerodynamic Decelerator, or HIAD, is essentially a doughnut-shaped heat shield made of soft, flexible materials. The system is like a cone of inflatable inner tubes that’s packed tightly into a spacecraft and automatically deployed to use atmospheric drag to slow a fast-moving capsule during descent.

NASA HIAD
The HIAD’s main rings look like giant inner tubes. (Image: NASA)

The innovative HIAD system is being examined for possible uses such as manned missions to Mars and landing cargo weighing more than 20 metric tons on other worlds.

“NASA was able to land the Mars Rover, but that is a pretty small device,” said Jacques Cuneo, a Southern Research engineer involved in the testing of HIAD’s materials. “If humans ever go to Mars, we will need to land many things with lots of mass – structures, supplies and other vital items.

“NASA will need to land large payloads, and, right now, they just can’t do it.”

When it comes to Mars, NASA’s mission planners must contend with an atmosphere that is roughly 100 times thinner than Earth’s and composed mostly of carbon dioxide, which can float to the planet’s frigid surface as snowflakes.

FOLDING TESTS

Southern Research’s assigned task in HIAD’s development centered on a key question posed by NASA’S Langley Research Center in Hampton, Virginia, according to Cuneo.

The HIAD’s inflatable structure is fashioned from a fastened series of pressurized concentric tubes, or tori, that form an exceptionally strong cone-shaped shield. The tori’s braided synthetic fibers are 15 times stronger than steel, according to NASA.

But would packing the inflatable aeroshell’s flexible materials into the tight confines of a spacecraft threaten the system’s performance and doom the mission?

Southern Research Cuneo HIAD
Jacques Cuneo is a Southern Research engineer who worked on the tests of the HIAD materials.

“When they fold this complex item, when they crunch it down, there is no way for them to get a regular fold,” Cuneo said. “It’s going to end up crumpled, it’s going to have kinks. There is definite randomness in what happens.

“It’s not like a parachute where they nicely fold it up and pack it in every time,” he added. “After they fold HIAD up, they compress it, so there is going to be some damage. The question is whether it can withstand this damage.”

The Southern Research team designed an extensive series of tests to provide an answer.

The engineers conducted folding studies meant to generate a wide range of creases and folds in the flexible HIAD materials during the packing process. They then evaluated specimens of the materials in strength-retention and permeation tests.

“We were looking to see what kind of property retention it has and what kind of damage occurred while it was folded up,” Cuneo said. “We folded it up loosely, we folded it up tightly. We introduced a lot of different conditions to see how it was going to perform, and the material actually did really well.

“That gave NASA confidence that what they are doing makes sense, and that catastrophic damage was not going to result from the folding operation,” he added.

COMPRESSION TESTS

Last year, NASA put HIAD through a key field test. Engineers used a vacuum pump to compress a 9-foot diameter prototype of the inflatable heat shield into the tight confines of a spacecraft. They then checked the materials for leaks and damage.

After that successful test, NASA said its engineers will move forward with the development of a larger HIAD that can withstand the stress of being tightly packed in a rocket and the challenges experienced when it descends through the atmosphere of a planet such as Mars.

NASA inflatable heat-shield
The materials making up the HIAD system would be compressed into a compartment on a spacecraft. (Image: NASA)

Cuneo said the innovative technology holds promise as NASA contends with the challenges of landing large volumes of supplies, scientific instruments and equipment on worlds with thin atmospheres.

“HIAD has an excellent shot at being utilized down the road for these types of missions,” he said. “It might be Mars or a moon of Jupiter. The technology is there to utilize.”

NASA PARTNERSHIP

Birmingham-based Southern Research has a long history of collaboration with NASA, dating back to the early days of the Apollo program. As part of that work, engineers analyzed the thermal and mechanical properties of potential shield materials and developed mathematical models to predict their performance in re-entry conditions.

Southern Research conducted similar work for the Space Shuttle program, while also remedying a potentially catastrophic rocket nozzle problem and helping the NASA “Return to Flight” missions after the Columbia accident.

Today, the organization is involved in the Space Launch System, or SLS, the massive rocket NASA is developing for planned Mars missions.

“The unique talents of Southern Research’s engineers have contributed to many of NASA’s most significant projects over the decades, and that’s continuing today as the space agency plans epic missions to land astronauts on Mars,” said Michael D. Johns, the organization’s vice president of Engineering.