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Since its founding in 1941, Southern Research has participated in the development of approximately half of all FDA-approved anticancer drugs. Our cancer therapeutics professionals evaluate hundreds of compounds yearly to establish their in vitro and/or in vivo efficacy potential. This experience enables us to design optimal studies that provide critical preclinical anticancer efficacy data for our clients’ drug development programs.

Services

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As a full-service nonclinical CRO, Southern Research offers clients a full continuum of drug development services. By providing histopathology, clinical pathology, and bioanalytical services in-house, Southern Research more efficiently moves a client’s drug down the development pipeline to IND submission. An in vitro efficacy program can quickly move to in vivo efficacy. Once efficacy has been established and optimized, a program can seamlessly transition to safety assessment in our Preclinical Toxicology Department.

 

  • In Vitro
    • Proliferation
    • Cytotoxicity
    • 3D Tumor spheroid
    • Microfluidic tumor model
    • Colony formation
    • Mechanism of action (MOA)
    • Invasion/migration
    • Apoptosis
    • Cell cycle
    • Angiogenesis
    • Receptor binding
    • Combination (drug-drug and drug radiation)
    • Combination sequencing & scheduling
    • Consulting services
    • Custom model development
  • In Vivo
    • Human xenograft tumors
    • Syngeneic mouse tumors
      • Including 2 metastasis models
    • HPV positive syngeneic tumor model
    • Combination sequencing and scheduling
      • Drug-Drug
      • Drug-Radiation
      • Drug-IO
      • IO-IO
    • Human immune reconstituted mouse
    • Maximum tolerated dose (MTD)
    • Pharmacokinetics (PK), tumor-bearing
    • Biodistribution, tumor-bearing
    • Consulting services
    • Custom model development
  • Consulting

    Southern Research Oncology Scientists average over 15 years of cancer therapeutic development experience. We offer our clients access to these years of knowledge through our Consulting Services.

    We can provide consulting from Chemistry though Lead Identification/Optimization, Safety Assessment, Compound Scale-up, and Production.

     

  • Key Capabilities

    Southern Research provides access to a broad range of capabilities that allow for the establishment of custom research programs.

    • Label-free, real-time analysis (xCELLigence)
    • Flow cytometry, including FACS
    • Magnetic cell enrichment
    • High-content imaging
    • Confocal microscopy
    • High throughput screening (HTS)
    • In vitro/In vivo irradiator
    • Biolayer interferometry (Octet assay system)
    • BSL-2 in vitro & in vivo labs
    • Large vivarium capacity
    • Molecular biology
    • Immunology
    • Histopathology
    • Clinical pathology
    • Bioanalytical services
    • qPCR
    • Oncology Consulting services including
      • Chemistry
      • Lead identification
      • Lead optimization
      • Safety assessment
      • Compound scale-up
      • Production

Solutions

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Southern Research offers a customized approach to oncology therapeutic development. We are experienced in evaluating chemotherapeutic agents, antibody therapeutics, oncolytic viruses, prophylactic and therapeutic vaccines, and radiation sensitizers. Our newest service offerings are in support of immuno-oncology (IO) therapeutic development and include classic syngeneic mouse tumor models.

  • Small Molecule Development

    For over 60 years Southern Research has played a key role in development of many of the small molecule cancer therapeutics that have saved or prolonged patient lives. Southern Research stands ready to apply our experience gained from assisting in the development of nearly half of all the approved small molecule cancer therapeutics to your small molecule cancer therapeutic program.

    • Services
      • Chemistry (consulting)
      • High Throughput Screening
      • In vitro efficacy
      • Mechanism of action
      • Syngeneic & Xenograft models
      • Radiation sensitization
      • Combination sequencing and scheduling
      • Pharmacokinetics
      • Biodistribution
      • IND-enabling toxicology
    • Staff resources
      • Chemists
      • Cancer biologists
      • Cell & molecular biologists
      • Radiation biologist
      • Pathologists
      • Toxicologists
    • Support services
      • Chemistry
      • Histopathology
      • Clinical Pathology
      • Bioanalytical
  • Immuno-Oncology Development

     

    • Services
      • In vitro efficacy
      • Combination sequencing and scheduling
      • Syngeneic mouse models
      • Immune characterization
      • Flow cytometry, including FACS
      • Multiplex immunoassays, cytokine panels
      • Immunogenicity
      • Pharmacokinetics
      • Biodistribution
      • IND-enabling toxicology
    • Tumor Model Systems
      • Syngeneic Mouse Models
        • MC38, CT26.WT, Colon 26, EMT-6, B16/F10, PAN02, Lewis Lung, RENCA, TC-1 (HPV+) and 4T1
    • Staff resources
      • Cancer biologists
      • Radiation biologists
      • Immunologists
      • Pathologists
      • Toxicologists
    • Support services
      • Histopathology
      • Clinical Pathology
      • Immunology
      • Bioanalytical
  • Oncolytic Virus Development

    Southern Research ran our first oncolytic virus study in 2006.  Since those early days, we have continued to evolve services to be able to provide a coordinated package of virology, immunology, tumor biology, and toxicology services to support even the most ambitious oncolytic virus development program.

    • Virus types
      • Adenoviruses
      • Adeno-Associated Viruses
      • Enteroviruses
      • Herpes Simplex Virus
      • Lentivirus
      • Measles Virus
      • Newcastle Disease Virus
      • Vaccinia Virus
      • Vesicular Stomatitis Virus
      • Others, as needed
    • Services
      • In vitro and in vivo efficacy
      • Plaque assay for dose confirmation and biodistribution
      • qPCR for biodistribution and transgene expression analysis
      • Immune characterization
      • Flow cytometry
      • Multiplexed immunoassays
      • Immunogenicity
      • IND-enabling toxicology
      • Neurovirulence and neuropathology
      • Clinical trial sample analysis
    • Staff resources
      • Cancer biologists
      • Virologists
      • Immunologists
      • Pathologists
      • Toxicologists
    • Support services
      • Immunology
      • Histopathology
      • Clinical Pathology
      • Bioanalytical
  • Cancer Vaccine Development

    Prophylactic, therapeutic, antigen, DNA, and RNA, Southern Research is experienced in working with all cancer vaccine platforms.

    • Services
      • In vivo efficacy
      • Immune characterization
        • Flow cytometry
        • Multiplexed immunoassays
        • Immunogenicity
      • IND-enabling toxicology
      • Biomarkers
      • Clinical trial sample analysis
    • Staff Resources
      • Cancer biologists
      • Immunologists
      • Pathologists
      • Toxicologists
    • Support services
      •  Immunology
      • Histopathology
      • Clinical Pathology
      • Bioanalytical