The Infectious Diseases Department maintains an advanced, well-established research program focused on disease-causing mechanisms for a diverse array of pathogens. The Department is dedicated to identifying novel mechanisms, targets and strategies for prevention and treatment of both bacterial and viral infectious diseases throughout the world. The bacteriology program is focused on the study of the molecular pathogenesis of relevant fastidious, re-emerging and multidrug-resistant bacteria to develop new treatments using novel approaches. The program uses phage technology for the creation of: 1) specific phage therapies as alternatives to the use of antibiotics, and 2) novel vaccines to present antigens through phage display technology. Our current focus is on pathogens such as Vibrio cholerae (primarily as a model system), Pseudomonas aeruginosa (in the context of cystic fibrosis), Salmonella sp. and the re-emerging pathogen Bordetella pertussis. The virology program focuses on viruses of global health significance, such as Encephalitic Alphaviruses, Flaviviruses, Influenza (including seasonal, pandemic, and avian (H5N1) strains), Ebola and Marburg. The program concentrates on several critical areas including viral pathogenesis at the cellular and molecular levels, target identification and development of novel target-based assays, discovery of small molecule antivirals, and development of contemporary vaccines.
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