SHERBROOKE, Quebec and BIRMINGHAM, Ala. — Cyclenium Pharma Inc., an emerging pharmaceutical company specializing in the research and development of novel drug candidates based on proprietary macrocyclic chemistry, today announced the signing of a discovery and co-development agreement with Southern Research Institute, a not-for-profit 501(c)(3) scientific research organization founded in 1941. The collaboration will utilize Cyclenium’s proprietary libraries of next generation macrocyclic molecules and associated hit-to-lead optimization expertise in combination with Southern Research’s extensive capabilities in target screening, compound profiling and preclinical development. The goal is to discover and jointly develop new clinical candidates for the treatment of cancer, infectious diseases and neurological conditions.

“We are very pleased to have initiated this collaboration with a prestigious organization like Southern Research,” stated Helmut Thomas, Ph.D., President & CEO of Cyclenium. “Their breadth of expertise and long history of successful contributions to drug discovery and development will provide strong synergy for our proprietary macrocyclic technology with the expectation of multiple novel candidates resulting from our joint efforts over the next few years.”

“Cyclenium’s proprietary macrocyclic libraries are well suited for use against many of the challenging targets we are currently working on,” stated Mark J. Suto, Ph.D. Vice-President Drug Discovery Division Southern Research Institute. “For example, screening of currently available small molecule libraries has not been very successful in the identification of new antibiotics and in targets associated with disrupting protein-protein interactions. The Cyclenium macrocycle libraries are unique in that they combine the complexities found in natural products with the drug-like properties needed for successful drug discovery. We are looking forward to collaborating with Cyclenium in the identification of new therapeutics.”

About Cyclenium Pharma

Cyclenium Pharma is an emerging pharmaceutical research and development company pursuing development of selected product opportunities in areas of unsatisfied medical need, while simultaneously creating a second generation macrocyclic drug discovery technology. Cyclenium is building value through progression of internal programs and establishing collaborations with innovative pharmaceutical and biotechnology companies seeking to modulate difficult disease targets. For more on Cyclenium Pharma, please see: www.cyclenium.com.

About Southern Research Institute

Southern Research Institute is a not-for-profit 501(c)(3) scientific research organization founded in 1941 that conducts preclinical drug discovery and development, advanced engineering research in materials, systems development, and environment and energy research. Approximately 500 scientific and engineering team members support clients and partners in the pharmaceutical, biotechnology, defense, aerospace, environmental and energy industries. From discovery to clinical trials, Southern Research contributes to the search for new and better drugs and vaccines through a comprehensive continuum of capabilities. As a contract research organization, Southern Research provides preclinical drug development and clinical trial support services to pharmaceutical and biotechnology companies on an outsourced basis. Southern Research is headquartered in Birmingham, AL, with additional laboratories and offices in Wilsonville and Huntsville, AL, Frederick, MD, Durham, NC, Houston, TX, and Cartersville, GA. For more information visit: southernresearch.org.

Birmingham, Ala. – Southern Research Institute’s Engineering Division is part of a Torch Technologies proposed team that was recently awarded a contract with a potential value of $71 million to support Redstone Arsenal’s Aviation and Missile Research, Development, and Engineering Center’s (AMRDEC) System Simulation and Development Directorate (SSDD). The award will be used to support SSDD’s world-class facilities and enhance and maintain its current suite of missile element modeling, digital simulation, Hardware-in-the-Loop (HWIL) and prototype development facilities.

“We are pleased to be part of the team that was proposed by Torch for this opportunity,” said Michael D. Johns, Vice President, Engineering Division, Southern Research Institute. “We are also thankful to the Army for their confidence in the team formed by Torch.”

About Torch Technologies

Torch Technologies is a 100-percent employee-owned small business with over 320 employees dedicated to quality technical services, competitive costs, and ethical business practices headquartered in Huntsville, Ala., with employee-owners located in Colorado Springs, Colorado; Dahlgren, Virginia; Eglin AFB, Florida; Pacific Missile Range Facility, Hawaii; Reagan Test Site, Kwajalein; Washington, D.C.; and Vandenberg Air Force Base, California.

About Southern Research Institute

Southern Research Institute is a not-for-profit 501(c)(3) scientific research organization founded in 1941 that conducts advanced engineering research in materials, systems development, environment and energy research, and preclinical drug discovery and development. Approximately 500 scientific and engineering team members support clients and partners in the pharmaceutical, biotechnology, defense, aerospace, environmental and energy industries. Southern Research is headquartered in Birmingham, Ala., with additional laboratories and offices in Huntsville and Wilsonville, Ala., Frederick, Md., Durham, NC, and Cartersville, Ga.

Presentation “DNA Damage Response and Tumor Metastasis” to be Presented April 7, 2014 at ESTRO 33, the Premier European Event in Radiation Oncology

Birmingham, Ala. – Southern Research Institute today announced that the Institute’s translational radiation oncology research program in the Drug Discovery Division has been invited to present at a symposium during the European Society of Radiotherapy and Oncology (ESTRO) 33rd annual meeting being held in Vienna, Austria, April 4 – 8, 2014. Bo Xu, M.D., Ph.D., Chair, Oncology Research Department, Southern Research Institute, will speak at the conference, which attracts leading scientists from around the world, on April 7, in a clinical science symposium entitled: “DNA Damage Response and Tumor Metastasis”.

“We are proud to participate in the ESTRO 33 meeting, and pleased to have this important research recognized internationally at such a prestigious event,” said Mark J. Suto, Ph.D., Vice President, Drug Discovery Division, Southern Research Institute. The translational radiation oncology program led by Dr. Xu aims to understand molecular mechanisms of the DNA damage response and to develop molecularly targeted drugs to enhance the effectiveness of radiation therapy, a major treatment modality that almost two-third of cancer patients will need during the process of treatment. The molecular radiobiology laboratory is a part of the Cancer Research Program at Southern Research which has a long and successful history of oncology drug discovery.

To access information about the presentation and the ESTRO 33 meeting, go to the ESTRO 33 website: http://www.estro.org/congresses-meetings/items/estro-33.

About Southern Research Institute

Southern Research Institute is a not-for-profit 501(c)(3) scientific research organization founded in 1941 that conducts preclinical drug discovery and development, advanced engineering research in materials, systems development, and environment and energy research. Approximately 500 scientific and engineering team members support clients and partners in the pharmaceutical, biotechnology, defense, aerospace, environmental and energy industries. Southern Research is headquartered in Birmingham, AL, with additional laboratories and offices in Wilsonville and Huntsville, AL, Frederick, MD, Durham, NC, Houston, TX, and Cartersville, GA. For more information visit: http://52.55.231.133.

Oxidizer technology generates clean power from low quality or waste fuels

BIRMINGHAM, AL and DURHAM, NC – Southern Research Institute and Ener-Core, Inc. (OTCBB: ENCR) today announced that they have completed a field demonstration and performance verification of the Ener-Core FP250 PowerStation under the U.S. Dept. of Defense’s Environmental Security Technology Certification Program (ESTCP.)

“Thermal oxidizers are commonly used for air pollution control, but they don’t convert the waste gases into power” said Alain Castro, Ener-Core chief executive officer. “This demonstration verifies that Ener-Core has successfully adapted oxidizer technology to generate clean power from low quality or waste fuels, while at the same time destroying the contaminants in the waste fuels.” The FP250 employs a specially designed gradual thermal oxidizer to power a modified conventional 250kW micro-turbine, resulting in an electric power generating solution capable of operating with low heating value fuels while producing extremely low NOx emissions.

The field demonstration, which assessed the technical and economic performance of the FP250 over a nominal one-year monitoring period, was conducted at the 1st Division Road landfill located at Ft. Benning, Ga. Southern Research acted as the independent third-party verifier. Specific demonstration objectives included verifying net power production, low emissions, greenhouse gas emissions reductions, return on investment, reliability, and operability.

The FP250 installed at Ft. Benning produced a net of 220 kilowatts of electric power using untreated, low-quality landfill gas that was approximately 25 percent methane. Nitrogen oxide emissions were less than five percent of the stringent California Air Resources Board 2013 emissions standards for distributed generation equipment.

“Economically, the FP250 was shown to be on par with competing distributed generation technologies with a levelized cost of energy of 9.8 cents per kilowatt hour,” said Tim Hansen, Southern Research’s Principal Investigator and Director, Advanced Energy and Transportation Technology. Ener-Core officials project that the levelized cost of energy will drop to below eight cents per kilowatt hour once manufacturing of the FP250 ramps up, and below 5.5 cents per kilowatt hour with the larger power-station sizes which are being rolled out.

The demonstration was funded by the U.S. Dept. of Defense’s Environmental Security Technology Certification Program (ESTCP). The final report is published online at http://www.serdp.org/Program-Areas/Energy-and-Water/Energy/Distributed-Generation/EW-200823/EW-200823/(language)/eng-US

About Ener-Core, Inc.

Ener-Core, Inc. (“Ener-Core”) (OTCBB: ENCR) designs and manufactures innovative systems for producing continuous energy from a broad range of sources, including previously unusable ultra-low quality gas. The Ener-Core Gradual Oxidizer, our patented oxidation technology, enables the conversion of these gases into useful heat and power with the lowest known associated emissions. With the Ener-Core Gradual Oxidizer matched to gas turbines, Ener-Core offers systems with fuel flexibility and pollution control for power generation. The Gradual Oxidizer can also be customized for integration with larger existing power generation systems to offer unparalleled pollution control and achieve zero emissions.

About Southern Research Institute Pollution Control and Energy Solutions

Southern Research Institute is an international leader in the evaluation of emission reduction technologies, including air pollution measurement and control, as well as the assessment of advanced renewable and bioenergy technologies. Over the past 40 years, Southern Research has invented, designed, or developed a number of reference methods and devices now widely used in the industry, earning the Institute a reputation for excellence in particulate control research, emissions measurement, and the appraisal of advanced energy systems.

About Southern Research Institute

Southern Research Instituteis a not-for-profit 501(c)(3) scientific research organization founded in 1941 that conducts preclinical drug discovery and development, advanced engineering research in materials, systems development, and environment and energy research. Approximately 500 scientific and engineering team members support clients and partners in the pharmaceutical, biotechnology, defense, aerospace, environmental and energy industries. Southern Research is headquartered in Birmingham, Ala., with additional laboratories and offices in Wilsonville and Huntsville, Ala., Frederick, Md., Durham, NC, Houston, TX, and Cartersville, Ga.

Booth #1525, South Hall, Von Braun Center, Huntsville, Alabama

Birmingham, AL – Southern Research Institute announced today that representatives of the Engineering Division will be exhibiting at the 2014 Association of the United States Army’s Institute of Land Warfare (AUSA) Winter Symposium, to be held February 19-21, 2014 at the Von Braun Center in Huntsville, Alabama.

AUSA Winter Symposium attendees can learn more about Southern Research Institute Engineering Division’s advances in aerospace engineering, composite structures development and design, fabrication, integration, and field support for electro-mechanical systems for ISR, test, and tracking by visiting the Institute’s booth, #1525 in the south hall of the Von Braun Center during the Symposium.

About the 2014 AUSA Winter Symposium

The Association of the United States Army’s Institute of Land Warfare (AUSA) Winter Symposium and Exposition is a professional development forum for members of industry and the military community. The event includes featured presentations from the United States Army Materiel Command, the United States Army Training and Doctrine Command, and the Office of the Assistant Secretary of the Army (Acquisition, Logistics and Technology). For more information visit: http://ausameetings.org/winter.

About Southern Research Institute’s Aerospace Solutions

Southern Research Institute’s Engineering Division provides research and development in the areas of aerospace engineering, thermal and structural behaviors of advanced composite materials, composite structures development and production, computational sciences and data processing as well as design, fabrication, integration, and field support for electro-mechanical systems for ISR, test, and tracking. The Engineering Division’s labs include resources for extreme environment & structural testing and fabrication for quick reaction capabilities (QRC) and low rate initial production (LRIP) efforts.

About Southern Research Institute

Southern Research Institute is a not-for-profit 501(c)(3) scientific research organization founded in 1941 that conducts preclinical drug discovery and development, advanced engineering research in materials, systems development, and environment and energy research. Approximately 500 scientific and engineering team members support clients and partners in the pharmaceutical, biotechnology, defense, aerospace, environmental and energy industries. Southern Research is headquartered in Birmingham, AL, with additional laboratories and offices in Wilsonville and Huntsville, AL, Frederick, MD, Durham, NC, Houston, TX, and Cartersville, GA. For more information visit: http://52.55.231.133.